Tumours induced in Fischer 344 rats by the feeding of disulfiram together with sodium nitrite
Lijinsky, W; Reuber, MD
HERO ID
3805836
Reference Type
Journal Article
Year
1980
Language
English
PMID
| HERO ID | 3805836 |
|---|---|
| In Press | No |
| Year | 1980 |
| Title | Tumours induced in Fischer 344 rats by the feeding of disulfiram together with sodium nitrite |
| Authors | Lijinsky, W; Reuber, MD |
| Journal | Food and Cosmetics Toxicology |
| Volume | 18 |
| Issue | 1 |
| Page Numbers | 85-87 |
| Abstract | A mixture of 0·1% disulfiram together with 0·2% sodium nitrite in powdered rat diet was fed to 20 male and 20 female Fischer 344 rats for 78 wk, after which the animals were observed until death. Ten of the males and 12 of the females died with tumours of the oesophagus, tongue, squamous stomach and nasal cavity. None of these tumours was observed in rats fed either disulfiram or sodium nitrite alone at similar doses. The tumours were attributed to the reaction of disulfiram and nitrite in the stomach, with the formation of nitrosodiethylamine, which has given rise to these tumours in Fischer rats from the same colony. |
| Doi | 10.1016/0015-6264(80)90016-4 |
| Pmid | 7372216 |
| Wosid | WOS:A1980JM31600015 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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