DPOAEs in infants developmentally exposed to PCBs show two differently time spaced exposure sensitive windows
Koštiaková, V; Moleti, A; Wimmerová, S; Jusko, TA; Palkovičová Murínová, Ľ; Sisto, R; Richterová, D; Kováč, J; Čonka, K; Patayová, H; Tihányi, J; Trnovec, T
HERO ID
3789571
Reference Type
Journal Article
Year
2016
Language
English
PMID
| HERO ID | 3789571 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | DPOAEs in infants developmentally exposed to PCBs show two differently time spaced exposure sensitive windows |
| Authors | Koštiaková, V; Moleti, A; Wimmerová, S; Jusko, TA; Palkovičová Murínová, Ľ; Sisto, R; Richterová, D; Kováč, J; Čonka, K; Patayová, H; Tihányi, J; Trnovec, T |
| Journal | Chemosphere |
| Volume | 161 |
| Page Numbers | 518-526 |
| Abstract | The study aim was to identify the timing of sensitive windows for ototoxicity related to perinatal exposure to PCBs. A total of 351 and 214 children from a birth cohort in eastern Slovakia underwent otoacoustic testing at 45 and 72 months, respectively, and distortion product otoacoustic emissions (DPOAEs) at 11 frequencies were recorded. Cord and child 6-, 16-, 45-, and 72- month blood samples were analyzed for PCB 153 concentration. The PCB 153 concentration-time profiles were approximated with a system model to calculate area under the PCB*time curves (AUCs) for specific time intervals (3 and 6 months for 45 and 72 months data, respectively). DPOAE amplitudes were correlated (Spearman) with cord serum PCB and AUCs, markers of prenatal and postnatal exposure, respectively. Two exposure critical windows were identified in infants, the first related to prenatal and early postnatal and the second to postnatal exposure to PCBs. Our data have shown tonotopicity, sexual dimorphism, and asymmetry in ototoxicity of PCBs. |
| Doi | 10.1016/j.chemosphere.2016.07.045 |
| Pmid | 27470944 |
| Wosid | WOS:000382409200062 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |