Topical application of penetration enhancers to the skin of nude mice: A histopathological study
Lashmar, UT; Hadgraft, J; Thomas, N
HERO ID
3539872
Reference Type
Journal Article
Year
1989
Language
English
PMID
| HERO ID | 3539872 |
|---|---|
| In Press | No |
| Year | 1989 |
| Title | Topical application of penetration enhancers to the skin of nude mice: A histopathological study |
| Authors | Lashmar, UT; Hadgraft, J; Thomas, N |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 41 |
| Issue | 2 |
| Page Numbers | 118-122 |
| Abstract | Eighteen potential penetration enhancers, some at concentrations that might be used for that purpose, have been examined to evaluate their irritancy potential on nude mouse skin. A biopsy technique was employed followed by histological examination. Up to 50% glycerol, 10% hydroxyethyl lactamide (HELA), 10% oleyl alcohol, 10% Solketal, 10% glycofurol, 100% tetrahydrofurfuryl alcohol (THFA) and 10% urea induced no discernible change in the histological appearance of the skin whereas 100% dimethyl sulphoxide (DMSO), 100% dimethyl formamide (DMF), 100% N-methyl-2-pyrrolidone, 10% Azone, 10% oleic acid, 10% methyl laurate, 10% benzyl alcohol and 10% glycerol formal caused severe skin irritation. |
| Doi | 10.1111/j.2042-7158.1989.tb06405.x |
| Pmid | 2568419 |
| Wosid | WOS:A1989U062900014 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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