In situ forming implants for periodontitis treatment with improved adhesive properties
Do, MP; Neut, C; Delcourt, E; Seixas Certo, T; Siepmann, J; Siepmann, F
| HERO ID | 3539768 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | In situ forming implants for periodontitis treatment with improved adhesive properties |
| Authors | Do, MP; Neut, C; Delcourt, E; Seixas Certo, T; Siepmann, J; Siepmann, F |
| Journal | European Journal of Pharmaceutics and Biopharmaceutics |
| Volume | 88 |
| Issue | 2 |
| Page Numbers | 342-350 |
| Abstract | Novel in situ forming implants are presented showing a promising potential to overcome one of the major practical hurdles associated with local periodontitis treatment: limited adhesion to the surrounding tissue, resulting in accidental expulsion of at least parts of the implants from the patients' pockets. This leads to high uncertainties in the systems' residence times at the site of action and in the resulting drug exposure. In the present study, the addition of different types and amounts of plasticizers (acetyltributyl citrate and dibutyl sebacate) as well as of adhesive polymers (e.g., cellulose derivatives such as hydroxypropyl methylcellulose) is shown to allow for a significant increase in the stickiness of poly(lactic-co-glycolic acid)-based implants. The systems are formed in situ from N-methyl pyrrolidone-based liquid formulations. Importantly, at the same time, good plastic deformability of the implants can be provided and desired drug release patterns can be fine-tuned using several formulation tools. The antimicrobial activity of this new type of in situ forming implants, loaded with doxycycline hyclate, was demonstrated using the agar well diffusion method and multiple Streptococcus strains isolated from the oral microflora of patients suffering from periodontitis. |
| Doi | 10.1016/j.ejpb.2014.05.006 |
| Pmid | 24833006 |
| Wosid | WOS:000345724400006 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V ISSN: 1873-3441 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Drug delivery; Agar; Antimicrobial activity; Deformability; Cellulose; Plasticizers; methylcellulose; Cell adhesion; Periodontitis; Oral microflora; Diffusion; Plastics; Adhesives; Drugs; Doxycycline; Citric acid; Streptococcus; 2014) |
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