Subchronic feeding study in beagle dogs of N-methylpyrrolidone
Becci, PJ; Gephart, LA; Koschier, FJ; Johnson, WD; Burnette, LW
HERO ID
3539728
Reference Type
Journal Article
Year
1983
Language
English
PMID
| HERO ID | 3539728 |
|---|---|
| In Press | No |
| Year | 1983 |
| Title | Subchronic feeding study in beagle dogs of N-methylpyrrolidone |
| Authors | Becci, PJ; Gephart, LA; Koschier, FJ; Johnson, WD; Burnette, LW |
| Journal | Journal of Applied Toxicology |
| Volume | 3 |
| Issue | 2 |
| Page Numbers | 83-86 |
| Abstract | The potential toxicity of N-methylpyrrolidone was evaluated following dietary administration for 13 weeks to male and female beagle dogs at dosage levels of 25, 79 and 250 mg per kg body weight per day. Body weight gain and food consumption, hematological and clinical chemical data, and ophthalmic, gross and histopathological examinations were used to study possible toxicological or pathological effects. No statistically significant treatment-related effects that were judged to be biologically meaningful were seen in any parameters of either male or female animals exposed to N-methylpyrrolidone at any dose level. However, a dose-dependent decrease in body weight and increase in platelet count that correlated with increased megakaryocytes was observed. Serum cholesterol in males decreased with increasing doses. |
| Doi | 10.1002/jat.2550030206 |
| Pmid | 6886300 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |