Distinctive features of NREM parasomnia behaviors in parkinson's disease and multiple system atrophy
Ratti, PL; Sierra-Peña, M; Manni, R; Simonetta-Moreau, M; Bastin, J; Mace, H; Rascol, O; David, O
HERO ID
3539608
Reference Type
Journal Article
Year
2015
Language
English
PMID
| HERO ID | 3539608 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Distinctive features of NREM parasomnia behaviors in parkinson's disease and multiple system atrophy |
| Authors | Ratti, PL; Sierra-Peña, M; Manni, R; Simonetta-Moreau, M; Bastin, J; Mace, H; Rascol, O; David, O |
| Journal | PLoS ONE |
| Volume | 10 |
| Issue | 3 |
| Page Numbers | e0120973 |
| Abstract | <strong>OBJECTIVE: </strong>To characterize parasomnia behaviors on arousal from NREM sleep in Parkinson's Disease (PD) and Multiple System Atrophy (MSA).<br /><br /><strong>METHODS: </strong>From 30 patients with PD, Dementia with Lewy Bodies/Dementia associated with PD, or MSA undergoing nocturnal video-polysomnography for presumed dream enactment behavior, we were able to select 2 PD and 2 MSA patients featuring NREM Parasomnia Behviors (NPBs). We identified episodes during which the subjects seemed to enact dreams or presumed dream-like mentation (NPB arousals) versus episodes with physiological movements (no-NPB arousals). A time-frequency analysis (Morlet Wavelet Transform) of the scalp EEG signals around each NPB and no- NPB arousal onset was performed, and the amplitudes of the spectral frequencies were compared between NPB and no-NPB arousals.<br /><br /><strong>RESULTS: </strong>19 NPBs were identified, 12 of which consisting of 'elementary' NPBs while 7 resembling confusional arousals. With quantitative EEG analysis, we found an amplitude reduction in the 5-6 Hz band 40 seconds before NPBs arousal as compared to no-NPB arousals at F4 and C4 derivations (p<0.01).<br /><br /><strong>CONCLUSIONS: </strong>Many PD and MSA patients feature various NREM sleep-related behaviors, with clinical and electrophysiological differences and similarities with arousal parasomnias in the general population.<br /><br /><strong>SIGNIFICANCE: </strong>This study help bring to attention an overlooked phenomenon in neurodegenerative diseases. |
| Doi | 10.1371/journal.pone.0120973 |
| Pmid | 25756280 |
| Wosid | WOS:000351275700075 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |