Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease
Jung, JC; Lee, YH; Kim, SH; Kim, KJ; Kim, KM; Oh, S; Jung, YS
| HERO ID | 3539381 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease |
| Authors | Jung, JC; Lee, YH; Kim, SH; Kim, KJ; Kim, KM; Oh, S; Jung, YS |
| Journal | BMC Complementary and Alternative Medicine |
| Volume | 16 |
| Page Numbers | 19 |
| Abstract | <strong>BACKGROUND: </strong>Our previous study suggested that licorice has anti-inflammatory activity in lipopolysaccharide-stimulated microglial cells and anti-oxidative activity in tert-butyl hydroperoxide-induced oxidative liver damage. In this study, we evaluated the effect of licorice on chronic alcohol-induced fatty liver injury mediated by inflammation and oxidative stress.<br /><br /><strong>METHODS: </strong>Raw licorice was extracted, and quantitative and qualitative analysis of its components was performed by using LC-MS/MS. Mice were fed a liquid alcohol diet with or without licorice for 4 weeks.<br /><br /><strong>RESULTS: </strong>We have standardized 70% fermented ethanol extracted licorice and confirmed by LC-MS/MS as glycyrrhizic acid (GA), 15.77 ± 0.34 μg/mg; liquiritin (LQ), 14.55 ± 0.42 μg/mg; and liquiritigenin (LG), 1.34 ± 0.02 μg/mg, respectively. Alcohol consumption increased serum alanine aminotransferase and aspartate aminotransferase activities and the levels of triglycerides and tumor necrosis factor (TNF)-α. Lipid accumulation in the liver was also markedly induced, whereas the glutathione level was reduced. All these alcohol-induced changes were effectively inhibited by licorice treatment. In particular, the hepatic glutathione level was restored and alcohol-induced TNF-α production was significantly inhibited by licorice.<br /><br /><strong>CONCLUSION: </strong>Taken together, our data suggests that protective effect of licorice against alcohol-induced liver injury may be attributed to its anti-inflammatory activity and enhancement of antioxidant defense. |
| Doi | 10.1186/s12906-016-0997-0 |
| Pmid | 26801973 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |