Oxadiazole derivatives containing 1,4-benzodioxan as potential immunosuppressive agents against RAW264.7 cells
Sun, J; Cao, N; Zhang, XM; Yang, YS; Zhang, YB; Wang, XM; Zhu, HL
HERO ID
3539130
Reference Type
Journal Article
Year
2011
Language
English
PMID
| HERO ID | 3539130 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Oxadiazole derivatives containing 1,4-benzodioxan as potential immunosuppressive agents against RAW264.7 cells |
| Authors | Sun, J; Cao, N; Zhang, XM; Yang, YS; Zhang, YB; Wang, XM; Zhu, HL |
| Journal | Bioorganic & Medicinal Chemistry |
| Volume | 19 |
| Issue | 16 |
| Page Numbers | 4895-4902 |
| Abstract | A series of oxadiazole derivatives containing 1,4-benzodioxan (4a-4s) have been first synthesized for their potential immunosuppressive activity. Among the compounds, compound 4i showed the most potent biological activity against RAW264.7 cells (inhibition=37.66±2.34% for NO overproduction and IC(50)=0.05μM for iNOS). Docking simulation was performed to position compound 4i into the iNOS structure active site to determine the probable binding model. RT-PCR experiment results demonstrated that some of these compounds possessed good immunosuppressive activity against iNOS, especially for compound 4i. Therefore, compound 4i with potent inhibitory activity may be a potential agent. |
| Doi | 10.1016/j.bmc.2011.06.061 |
| Pmid | 21782456 |
| Wosid | WOS:000293503000022 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |