Rapid preparation of (methyl)malonyl coenzyme A and enzymatic formation of unusual polyketides by type III polyketide synthase from Aquilaria sinensis
Gao, BW; Wang, XH; Liu, X; Shi, SP; Tu, PF
| HERO ID | 3537907 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Rapid preparation of (methyl)malonyl coenzyme A and enzymatic formation of unusual polyketides by type III polyketide synthase from Aquilaria sinensis |
| Authors | Gao, BW; Wang, XH; Liu, X; Shi, SP; Tu, PF |
| Journal | Bioorganic & Medicinal Chemistry Letters |
| Volume | 25 |
| Issue | 6 |
| Page Numbers | 1279-1283 |
| Abstract | (Methyl)malonyl coenzyme A was rapidly and effectively synthesized by a two-step procedure involving preparation of N-hydroxysuccinimidyl (methyl)malonate from (methyl)Meldrum's acid, and followed by transesterification with coenzyme A. The synthesized (methyl)malonyl coenzyme A could be well accepted and assembled to 4-hydroxy phenylpropionyl coenzyme A by type III polyketide synthase from Aquilaria sinensis to produce dihydrochalcone and 4-hydroxy-3,5-dimethyl-6-(4-hydroxyphenethyl)-2H-pyrone as well as 4-hydroxy-3,5-dimethyl-6-(5-(4-hydroxyphenyl)-3-oxopentan-2-yl)-2H-pyrone. |
| Doi | 10.1016/j.bmcl.2015.01.045 |
| Pmid | 25677661 |
| Wosid | WOS:000350696000022 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Bioorganic & medicinal chemistry letters ISSN: 1464-3405 |
| Is Public | Yes |
| Language Text | English |