Toxicological review of trichloroethylene (CAS No. 79-01-6) in support of summary Information on the Integrated Risk Information System (IRIS)
HERO ID
3532116
Reference Type
Technical Report
Subtype
EPA Report
Year
2011
Language
English
| HERO ID | 3532116 |
|---|---|
| Material Type | EPA Report |
| Year | 2011 |
| Title | Toxicological review of trichloroethylene (CAS No. 79-01-6) in support of summary Information on the Integrated Risk Information System (IRIS) |
| Authoring Organization | U.S. Environmental Protection Agency |
| Publisher Text | U.S. Environmental Protection Agency |
| City | Washington, DC |
| Abstract | There is substantial potential for human exposure to trichloroethylene (TCE), as it has a widespread presence in ambient air, indoor air, soil, and groundwater. At the same time, humans are likely to be exposed to a variety of compounds that are either metabolites of TCE or which have common metabolites or targets of toxicity. Once exposed, humans, as well as laboratory animal species, rapidly absorb TCE, which is then distributed to tissues via systemic circulation, extensively metabolized, and then excreted primarily in breath as unchanged TCE or carbon dioxide, or in urine as metabolites. The purpose of this Toxicological Review is to provide scientific support and rationale for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to trichloroethylene. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of trichloroethylene |
| Report Number | EPA635R09011F |
| Ntis Number | PB2012100125 |
| Url | https://nepis.epa.gov/Exe/ZyPURL.cgi?Dockey=P100CB6V.txt |
| Is Certified Translation | No |
| Dupe Override | No |
| Number Of Pages | 1200 |
| Comments | ICF NOTE: 1097-TCE-3.pdf |
| Is Public | Yes |
| Language Text | English |
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