Effects of NO2 on immune responses
Lefkowitz, SS; Mcgrath, JJ; Lefkowitz, DL
HERO ID
34754
Reference Type
Journal Article
Year
1986
Language
English
PMID
| HERO ID | 34754 |
|---|---|
| In Press | No |
| Year | 1986 |
| Title | Effects of NO2 on immune responses |
| Authors | Lefkowitz, SS; Mcgrath, JJ; Lefkowitz, DL |
| Journal | Journal of Toxicology and Environmental Health |
| Volume | 17 |
| Issue | 2-3 |
| Page Numbers | 241-248 |
| Abstract | The effects of NO2 on immune reponses of mice were investigated. Mice were exposed to various concentrations of NO2 in inhalation chambers. After exposure the following parameters were measured: phagocytosis of polystyrene beads by both peritoneal and alveolar macrophages, production of antibody-forming cells from mice immunized with sheep erythrocytes, lymphocyte blastogenesis of splenic cells, and susceptibility to influenza virus. The production of antibody-forming cells was reduced in mice that were exposed to 5 ppm NO2. The serum antibody titers, phagocytosis, and other immune parameters measured were not affected. Exposure to NO2 did not affect mortality to influenza virus. These data indicate that certain immune parameters were altered by exposure to NO2 however, NO2 does not appear to be a major immunosuppressive factor at the concentrations tested. |
| Doi | 10.1080/15287398609530820 |
| Pmid | 3959113 |
| Wosid | WOS:A1986A683700009 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | 2 in NO2 is a subscriptJ. Toxicol. Environ. Health 17: 241-248.|WOS:A1986A683700009 |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |