Increased asthma medication use in association with ambient fine and ultrafine particles
von Klot, S; Wölke, G; Tuch, T; Heinrich, J; Dockery, DW; Schwartz, J; Kreyling, WG; Wichmann, HE; Peters, A
HERO ID
34706
Reference Type
Journal Article
Year
2002
Language
English
PMID
| HERO ID | 34706 |
|---|---|
| In Press | No |
| Year | 2002 |
| Title | Increased asthma medication use in association with ambient fine and ultrafine particles |
| Authors | von Klot, S; Wölke, G; Tuch, T; Heinrich, J; Dockery, DW; Schwartz, J; Kreyling, WG; Wichmann, HE; Peters, A |
| Journal | European Respiratory Journal |
| Volume | 20 |
| Issue | 3 |
| Page Numbers | 691-702 |
| Abstract | The association between particulate air pollution and asthma medication use and symptoms was assessed in a panel study of 53 adult asthmatics in Erfurt, Germany in winter 1996/1997. Number concentrations of ultrafine particles, 0.01-0.1 microm in diameter (NC0.01-0.1), mean 17,300.cm-3, and mass concentrations of fine particles 0.01-2.5 microm in diameter (MC0.01-2.5), mean 30.3 microg.m-3, were measured concurrently. They were not highly correlated (r=0.45). The associations between ambient particle concentrations and the prevalence of inhaled 'beta'2-agonist, corticosteroid use and asthma symptoms, were analysed separately with logistic regression models, adjusting for trend, temperature, weekend, holidays, and first order autocorrelation of the error. Cumulative exposures over 14 days of ultrafine and fine particles were associated with corticosteroid use. 'Beta'2-agonist use was associated with 5-day mean NC0.01-0.1 and MC0.01-2.5. The prevalence of asthma symptoms was associated with ambient particle concentrations. The results suggest that reported asthma medication use and symptoms increase in association with particulate air pollution and gaseous pollutants such as nitrogen dioxide. |
| Doi | 10.1183/09031936.02.01402001 |
| Pmid | 12358349 |
| Wosid | WOS:000178187100030 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB. Umlaut over o in Wolke.Eur. Respir. J. 20: 691-702. |WOS:000178187100030 |
| Is Public | Yes |
| Language Text | English |
| Keyword | asthma symptoms; inhaled beta(2)-agonists; inhaled corticosteroids; particulate air pollution; wheezing |
| Is Qa | No |