Prenatal exposure to persistent organochlorine pollutants and female reproductive function in young adulthood
Kristensen, SL; Ramlau-Hansen, CH; Ernst, E; Olsen, SF; Bonde, JP; Vested, A; Halldorsson, TI; Rantakokko, P; Kiviranta, H; Toft, G
HERO ID
3350740
Reference Type
Journal Article
Year
2016
Language
English
PMID
| HERO ID | 3350740 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Prenatal exposure to persistent organochlorine pollutants and female reproductive function in young adulthood |
| Authors | Kristensen, SL; Ramlau-Hansen, CH; Ernst, E; Olsen, SF; Bonde, JP; Vested, A; Halldorsson, TI; Rantakokko, P; Kiviranta, H; Toft, G |
| Journal | Environment International |
| Volume | 92-93 |
| Page Numbers | 366-372 |
| Abstract | <strong>BACKGROUND: </strong>The biopersistent organochlorine pollutants dichlorodiphenyldichloroethylene (p,p'-DDE), hexachlorobenzene (HCB) and polychlorinated biphenyls (PCBs) can be detected in humans worldwide. The chemicals can cross the placenta and may interfere with endogenous hormonal homeostasis.<br /><br /><strong>OBJECTIVES: </strong>To investigate effects on female reproduction following intrauterine exposure to selected biopersistent organochlorines.<br /><br /><strong>METHODS: </strong>We used data from a Danish pregnancy cohort with follow-up on 436 eligible daughters at approximately 20years of age. Information on age of menarche (n=335), menstrual cycle length (n=230) and serum concentrations of reproductive hormones (n=243) was obtained. Number of antral follicles was counted by vaginal ultrasound (n=147). Of 244 daughters who attended clinical examination, 170 used hormonal contraceptives and 74 were non-users. Concentrations of p,p'-DDE, HCB and six PCB congeners were analysed in maternal serum samples obtained in pregnancy week 30.<br /><br /><strong>RESULTS: </strong>Age of menarche and menstrual cycle length were found not to be statistically significant associated with prenatal organochlorine exposure. Among non-users of hormonal contraceptives with information on antral follicle number (n=43), daughters exposed to the highest tertile of p,p'-DDE had 28% (95% confidence interval (95% CI): 5; 46%) lower follicle number compared to the low-level exposed reference group. Those exposed to medium and higher levels of HCB had 30% (95% CI: 5; 48%) and 28% (95% CI: 7; 44%) lower follicle number compared to the reference group. Furthermore, maternal serum HCB concentrations were inversely associated with free androgen index among non-users of hormonal contraceptives (n=73). These associations were not found in users of hormonal contraceptives.<br /><br /><strong>CONCLUSIONS: </strong>Among non-users of hormonal contraceptives, we found indications of adverse long-term effects on female reproduction following prenatal exposure to biopersistent organochlorines. These findings may have wide implications for public health as intrauterine exposure occurs worldwide. |
| Doi | 10.1016/j.envint.2016.04.024 |
| Pmid | 27132162 |
| Wosid | WOS:000378951700039 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |