Serum Levels of Persistent Organic Pollutants and Insulin Secretion among Children Aged 7 to 9 Years: A Prospective Cohort Study
Park, SH; Ha, EH; Hong, YS; Park, H
HERO ID
3350709
Reference Type
Journal Article
Year
2016
Language
English
PMID
| HERO ID | 3350709 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Serum Levels of Persistent Organic Pollutants and Insulin Secretion among Children Aged 7 to 9 Years: A Prospective Cohort Study |
| Authors | Park, SH; Ha, EH; Hong, YS; Park, H |
| Journal | Environmental Health Perspectives |
| Volume | 124 |
| Issue | 12 |
| Page Numbers | 1924-1930 |
| Abstract | <strong>BACKGROUND: </strong>Persistent organic pollutants (POPs) are endocrine disruptors and have been suggested as possible risk factors for diabetes. Few studies have been performed to investigate this association among children.<br /><br /><strong>OBJECTIVES: </strong>In this study, we prospectively examined the relationship between the serum concentration of POPs and glucose metabolism in children.<br /><br /><strong>METHODS: </strong>Data were collected from the Ewha Birth & Growth Cohort Study, an ongoing birth cohort study initially constructed between 2001 and 2006. In 2010-2012, the POP concentration was measured in serum from a total of 214 children, aged 7 to 9 years. Using fasting glucose and insulin measurements at both baseline and the second year of follow-up, the homeostatic model assessment of beta-cell function (HOMA-β) and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. Multiple linear regression analysis and a linear mixed effects model were used to determine the relationship between POP tertiles and metabolic biomarkers.<br /><br /><strong>RESULTS: </strong>Compared with the lowest tertile of total marker PCBs, participants in the third tertile had decreased HOMA-β values, after adjustment for age, sex, body mass index z-score, mother's education, Ponderal Index, and history of breastfeeding (-18.94%; 95% confidence interval: -32.97%, -1.98%). In a linear mixed model, the HOMA-β values were still lower in subjects in the highest compared with the lowest tertile of total PCBs at the 2-year follow-up period (108.3 vs. 135.0, respectively).<br /><br /><strong>CONCLUSION: </strong>The results of the study suggested that exposure to POPs among children might affect insulin secretory function, which could lead to an increased risk of developing diabetes. |
| Doi | 10.1289/EHP147 |
| Pmid | 27266903 |
| Wosid | WOS:000390211200021 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |