Tris-(2,3-dibromopropyl) isocyanurate induces depression-like behaviors and neurotoxicity by oxidative damage and cell apoptosis in vitro and in vivo
Dong, ZJ; Hu, ZP; Zhu, HB; Li, N; Zhao, HJ; Mi, W; Jiang, WL; Hu, XH; Ye, L
HERO ID
3350560
Reference Type
Journal Article
Year
2015
Language
English
PMID
| HERO ID | 3350560 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Tris-(2,3-dibromopropyl) isocyanurate induces depression-like behaviors and neurotoxicity by oxidative damage and cell apoptosis in vitro and in vivo |
| Authors | Dong, ZJ; Hu, ZP; Zhu, HB; Li, N; Zhao, HJ; Mi, W; Jiang, WL; Hu, XH; Ye, L |
| Journal | Journal of Toxicological Sciences |
| Volume | 40 |
| Issue | 6 |
| Page Numbers | 701-709 |
| Abstract | Tris-(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO), an emerging brominated flame retardant, possesses the characteristics of candidate persistent organic pollutants and has displayed toxicity to fish and rodents. TDBP-TAZTO can pass through the blood-brain barrier and accumulate in the brain. TDBP-TAZTO might also induce neuronal cell toxicity. However, the neurotoxicity and mechanisms of TDBP-TAZTO have not yet been studied. We hypothesize that TDBP-TAZTO could induce neurotoxicity in mouse hippocampal neurons and SH-SY5Y cells. The mice were exposed to TDBP-TAZTO of 5 and 50 mg/kg by gavage, daily for 30 days. TDBP-TAZTO resulted in depression-like behaviors, which may be related with TDBP-TAZTO-induced upregulation of oxidative stress markers and overexpression of pro-apoptotic proteins in hippocampus. Furthermore, TDBP-TAZTO treatment for 48 hr (12.5, 25 and 50 µM) damaged SH-SY5Y cells, and led to cell apoptosis and oxidative stress in concentration-dependent manner. Our findings suggested that cell apoptosis and oxidative stress are important mechanisms in neurotoxicity induced by TDBP-TAZTO. |
| Doi | 10.2131/jts.40.701 |
| Pmid | 26558450 |
| Wosid | WOS:000366239500003 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Tris-(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO); Depression; Hippocampus; Oxidative stress; Apoptosis |
| Is Peer Review | Yes |