Hepatotoxic interactions of ethanol with allyl alcohol or carbon tetrachloride in rats
Berman, E; House, DE; Allis, JW; Simmons, JE
| HERO ID | 32567 |
|---|---|
| In Press | No |
| Year | 1992 |
| Title | Hepatotoxic interactions of ethanol with allyl alcohol or carbon tetrachloride in rats |
| Authors | Berman, E; House, DE; Allis, JW; Simmons, JE |
| Journal | Journal of Toxicology and Environmental Health |
| Volume | 37 |
| Issue | 1 |
| Page Numbers | 161-176 |
| Abstract | The effects of ethanol (64175) on allyl-alcohol (107186) and carbon-tetrachloride (56235) hepatotoxicity were studied in rats. The purpose of the study was to assess the potential for ethanol to interact with known liver toxicants when used as a solvent in the dosing vehicle. Male Fischer-344-rats were gavaged with 0, 0.05, 0.1, 0.2, or 0.5 milliliter per kilogram (ml/kg) ethanol or 21mg/kg allyl-alcohol or 20mg/kg carbon-tetrachloride alone or in combination daily for 14 days. Body weight was monitored. The rats were killed 24 hours after the last dose and livers were removed, weighed, and assayed for cytochrome P-450 (P450) and reduced glutathione (GSH). Liver sections were examined for histopathological changes. Blood samples were collected and analyzed for serum lactate-dehydrogenase (LDH), alkaline-phosphatase (ALP), alanine-aminotransferase (ALT), and aspartate-aminotransferase (AST). Ethanol alone did not significantly affect body weight gain, hepatic P450 or GSH content, or serum ALT, AST, LDH, or ALP activity. It did not cause any histologically evident liver damage, but did cause a dose related decrease in absolute and relative liver weight. The apparent threshold for these effects was between 0.05 and 0.1ml/kg. Allyl-alcohol alone caused significant increasesin absolute and relative liver weight and hepatic GSH concentration, and it induced periportal hepatocellular vacuolar degeneration. Carbon-tetrachloride alone caused significant increases in absolute and relative liver weight and serum ALT, AST, and ALP activities. It also induced centrilobular hepatocellular degeneration and necrosis. Coadministration with ethanol did not alter the effects of allyl-alcohol or carbon-tetrachloride. No significant interaction of ethanol with allyl-alcohol was determined, but a small interactive effect on body weight occurred with 0.5ml/kg ethanol and carbon-tetrachloride. The authors conclude that subacute concurrent exposure of ethanol with carbon-tetrachloride or allyl-alcohol at ethanol concentrations typically used in dosing vehicles does not cause an interactive effect or hepatotoxicity. |
| Doi | 10.1080/15287399209531663 |
| Pmid | 1522609 |
| Wosid | WOS:A1992JQ26200012 |
| Url | http://www.tandfonline.com/doi/pdf/10.1080/15287399209531663#.VIn_6THF9qE |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | J. Toxicol. Environ. Health 37: 161-176. |
| Is Public | Yes |
| Language Text | English |
| Is Qa | Yes |
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