Methanol poisoning: a rodent model with structural and functional evidence for retinal involvement
Murray, TG; Burton, TC; Rajani, C; Lewandowski, MF; Burke, JM; Eells, JT
| HERO ID | 32352 |
|---|---|
| In Press | No |
| Year | 1991 |
| Title | Methanol poisoning: a rodent model with structural and functional evidence for retinal involvement |
| Authors | Murray, TG; Burton, TC; Rajani, C; Lewandowski, MF; Burke, JM; Eells, JT |
| Journal | Archives of Ophthalmology |
| Volume | 109 |
| Issue | 7 |
| Page Numbers | 1012-1016 |
| Abstract | Methanol ingestion can lead to visual impairment, central nervous system dysfunction, or death. The extent of ocular involvement has been difficult to determine because the toxicity is restricted to humans and nonhuman primates due to species differences in methanol metabolism. A rodent model of methanol toxicity recently developed by us was used to evaluate retinal dysfunction in methanol poisoning. Formic acidemia and visual toxic reactions developed in methanol-intoxicated rats. Electroretinographic analysis indicated a significant early deficit in b-wave amplitude followed by a temporally delayed, lesser reduction in a-wave amplitude. Histologic evaluation of the eyes 60 hours after methanol administration revealed generalized retinal edema and vacuolation in the photoreceptors and retinal pigment epithelium. Ultrastructural examination showed swelling and disruption of the mitochondria in photoreceptor inner segments, optic nerve, and the retinal pigment epithelium. These studies document direct retinal involvement in this nonprimate model of methanol toxicity. |
| Doi | 10.1001/archopht.1991.01080070124049 |
| Pmid | 2064555 |
| Wosid | WOS:A1991FV41400038 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Arch. Ophthalmol. 109: 1012-1016. |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>Microscopy Techniques-Histology and Histochemistry</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-General</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biophysics-General Biophysical Techniques</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Pathology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Blood</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Sense Organs</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Sense Organs</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Nervous System-Pathology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxicology-General</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Rodentia-Unspecified</kw> |
| Is Qa | No |