Physiologically based pharmacokinetic modeling of perfluoroalkyl substances in the human body
Fàbrega, F; Kumar, V; Benfenati, E; Schuhmacher, M; Domingo, JL; Nadal, M
HERO ID
3223669
Reference Type
Journal Article
Year
2015
Language
English
| HERO ID | 3223669 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Physiologically based pharmacokinetic modeling of perfluoroalkyl substances in the human body |
| Authors | Fàbrega, F; Kumar, V; Benfenati, E; Schuhmacher, M; Domingo, JL; Nadal, M |
| Journal | Toxicological and Environmental Chemistry |
| Volume | 97 |
| Issue | 6 |
| Page Numbers | 814-827 |
| Abstract | Currently, there are limited data on the levels of perfluoroalkyl substances other than perfluorooctane sulfonic acid and perfluorooctanoic acid in the human body. Most of this information has been extracted from biological monitoring of plasma while the occurrence of perfluoroalkyl substances in other human tissues is rarely studied. The objective of the present study was to develop a physiologically based pharmacokinetic model to assess the concentration of perfluoroalkyl substances in human tissues, based on an existing model previously validated for perfluorooctane sulfonic acid and perfluorooctanoic acid. Experimental data on concentrations of perfluoroalkyl substances in human tissues from individuals in Tarragona County (Catalonia, Spain) were used to estimate the values of some distribution and elimination parameters needed for the simulation. No significant correlations were found between these parameters and the chain lengths. The model was finally validated for five perfluoroalkyl substances. |
| Doi | 10.1080/02772248.2015.1060976 |
| Wosid | WOS:000359795300010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | perfluoroalkyl substances; PBPK modeling; model validation; human body; elimination mechanisms |
| Is Peer Review | Yes |