Homeobox genes in embryogenesis and pathogenesis
Mark, M; Rijli, FM; Chambon, P
HERO ID
3222609
Reference Type
Journal Article
Subtype
Review
Year
1997
Language
English
PMID
| HERO ID | 3222609 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 1997 |
| Title | Homeobox genes in embryogenesis and pathogenesis |
| Authors | Mark, M; Rijli, FM; Chambon, P |
| Journal | Pediatric Research |
| Volume | 42 |
| Issue | 4 |
| Page Numbers | 421-429 |
| Abstract | The homeobox, a 60-amino acid-encoding DNA sequence, originally discovered in the genome of the fruit fly Drosophila, was subsequently identified throughout the three kingdoms of multicellular organisms. Homeobox-containing genes encode DNA-binding proteins that regulate gene expression and control various aspects of morphogenesis and cell differentiation. In particular, the Hox family of clustered homeobox genes plays a fundamental role in the morphogenesis of the vertebrate embryo, providing cells with regional information along the main body axis. The nonclustered or divergent homeobox genes include a large number of genes scattered throughout the genome that, nevertheless, can be organized in distinct families based on their homologies and functional similarities. This review will provide the reader with a brief overview on some recent studies aimed at understanding the functional role of homeobox genes in normal mammalian development as well as their involvement in congenital malformations and oncogenesis. |
| Doi | 10.1203/00006450-199710000-00001 |
| Pmid | 9380431 |
| Wosid | WOS:A1997XX21500001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |