CaCl2, Bisoxazoline, and Malonate: A Protocol for an Asymmetric Michael Reaction
Lippur, K; Kaabel, S; Järving, I; Rissanen, K; Kanger, T
| HERO ID | 3120733 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | CaCl2, Bisoxazoline, and Malonate: A Protocol for an Asymmetric Michael Reaction |
| Authors | Lippur, K; Kaabel, S; Järving, I; Rissanen, K; Kanger, T |
| Journal | Journal of Organic Chemistry |
| Volume | 80 |
| Issue | 12 |
| Page Numbers | 6336-6341 |
| Abstract | A mild protocol for the asymmetric Michael addition of dimethyl malonate to various α,β-unsaturated carbonyl compounds was developed. The salient feature of this methodology is that a cheap and environmentally friendly Lewis acid, CaCl2, was used as a catalyst. An aminoindanol- and pyridine-derived ligand provided in the presence of CaCl2 Michael adducts in moderate to high enantioselectivities. The scope of the reaction was demonstrated. |
| Doi | 10.1021/acs.joc.5b00769 |
| Pmid | 26035234 |
| Wosid | WOS:000356845800034 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |