Associations between ultrafine and fine particles and mortality in five central European cities - Results from the UFIREG study
Lanzinger, S; Schneider, A; Breitner, S; Stafoggia, M; Erzen, I; Dostal, M; Pastorkova, A; Bastian, S; Cyrys, J; Zscheppang, A; Kolodnitska, T; Peters, A
HERO ID
3120093
Reference Type
Journal Article
Year
2016
Language
English
PMID
| HERO ID | 3120093 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Associations between ultrafine and fine particles and mortality in five central European cities - Results from the UFIREG study |
| Authors | Lanzinger, S; Schneider, A; Breitner, S; Stafoggia, M; Erzen, I; Dostal, M; Pastorkova, A; Bastian, S; Cyrys, J; Zscheppang, A; Kolodnitska, T; Peters, A |
| Journal | Environment International |
| Volume | 88 |
| Page Numbers | 44-52 |
| Abstract | <strong>BACKGROUND: </strong>Evidence on health effects of ultrafine particles (UFP) is still limited as they are usually not monitored routinely. The few epidemiological studies on UFP and (cause-specific) mortality so far have reported inconsistent results.<br /><br /><strong>OBJECTIVES: </strong>The main objective of the UFIREG project was to investigate the short-term associations between UFP and fine particulate matter (PM)<2.5μm (PM2.5) and daily (cause-specific) mortality in five European Cities. We also examined the effects of PM<10μm (PM10) and coarse particles (PM2.5-10).<br /><br /><strong>METHODS: </strong>UFP (20-100nm), PM and meteorological data were measured in Dresden and Augsburg (Germany), Prague (Czech Republic), Ljubljana (Slovenia) and Chernivtsi (Ukraine). Daily counts of natural and cardio-respiratory mortality were collected for all five cities. Depending on data availability, the following study periods were chosen: Augsburg and Dresden 2011-2012, Ljubljana and Prague 2012-2013, Chernivtsi 2013-March 2014. The associations between air pollutants and health outcomes were assessed using confounder-adjusted Poisson regression models examining single (lag 0-lag 5) and cumulative lags (lag 0-1, lag 2-5, and lag 0-5). City-specific estimates were pooled using meta-analyses methods.<br /><br /><strong>RESULTS: </strong>Results indicated a delayed and prolonged association between UFP and respiratory mortality (9.9% [95%-confidence interval: -6.3%; 28.8%] increase in association with a 6-day average increase of 2750particles/cm(3) (average interquartile range across all cities)). Cardiovascular mortality increased by 3.0% [-2.7%; 9.1%] and 4.1% [0.4%; 8.0%] in association with a 12.4μg/m(3) and 4.7μg/m(3) increase in the PM2.5- and PM2.5-10-averages of lag 2-5.<br /><br /><strong>CONCLUSIONS: </strong>We observed positive but not statistically significant associations between prolonged exposures to UFP and respiratory mortality, which were independent of particle mass exposures. Further multi-centre studies are needed investigating several years to produce more precise estimates on health effects of UFP. |
| Doi | 10.1016/j.envint.2015.12.006 |
| Pmid | 26708280 |
| Wosid | WOS:000371359300007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Ultrafine particles; Particulate matter; Mortality; Central Europe; Time series |
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