Long-and short-term exposure to air pollution and inflammatory/hemostatic markers in midlife women
Green, R; Broadwin, R; Malig, B; Basu, R; Gold, EB; Qi, L; Sternfeld, B; Bromberger, JT; Greendale, GA; Kravitz, HM; Tomey, K; Matthews, K; Derby, C; Jackson, EA; Green, R; Ostro, B
HERO ID
3075504
Reference Type
Journal Article
Year
2016
Language
English
PMID
| HERO ID | 3075504 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Long-and short-term exposure to air pollution and inflammatory/hemostatic markers in midlife women |
| Authors | Green, R; Broadwin, R; Malig, B; Basu, R; Gold, EB; Qi, L; Sternfeld, B; Bromberger, JT; Greendale, GA; Kravitz, HM; Tomey, K; Matthews, K; Derby, C; Jackson, EA; Green, R; Ostro, B |
| Journal | Epidemiology |
| Volume | 27 |
| Issue | 2 |
| Page Numbers | 211-220 |
| Abstract | <strong>BACKGROUND: </strong>Studies have reported associations between long-term air pollution exposures and cardiovascular mortality. The biological mechanisms connecting them remain uncertain.<br /><br /><strong>METHODS: </strong>We examined associations of fine particles (PM2.5) and ozone with serum markers of cardiovascular disease risk in a cohort of midlife women. We obtained information from women enrolled at six sites in the multi-ethnic, longitudinal Study of Women's Health Across the Nation, including repeated measurements of high-sensitivity C-reactive protein (hs-CRP), fibrinogen, tissue-type plasminogen activator antigen (tPA-ag), plasminogen activator inhibitor Type 1 (PAI-1), and Factor VIIc (Factor VII coagulant activity). We obtained residence-proximate PM2.5 and ozone monitoring data for a maximum five annual visits, calculating prior year, six-month, one-month, and one-day exposures and their relations to serum markers using longitudinal mixed models.<br /><br /><strong>RESULTS: </strong>For the 2,086 women studied from 1999 through 2004,PM2.5 exposures were associated with all blood markers except Factor VIIc after adjusting for age, race/ethnicity, education, site, body mass index, smoking, and recent alcohol use. Adjusted associations were of the strongest for prior year exposures for hs-CRP (21% increase per 10 µg/m PM2.5, 95% CI: 6.6, 37), tPA-ag (8.6%, 95% CI: 1.8, 16), and PAI-1 (35%, 95% CI: 19, 53). An association was also observed between year prior ozone exposure and Factor VIIc (5.7% increase per 10 ppb ozone, 95% CI: 2.9, 8.5).<br /><br /><strong>CONCLUSIONS: </strong>Our findings suggest that prior year exposures to PM2.5 and ozone are associated with adverse effects on inflammatory and hemostatic pathways for cardiovascular outcomes in midlife women. |
| Doi | 10.1097/EDE.0000000000000421 |
| Pmid | 26600256 |
| Wosid | WOS:000369866900008 |
| Url | https://journals.lww.com/epidem/Fulltext/2016/03000/Long__and_Short_term_Exposure_to_Air_Pollution_and.8.aspx |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | DOI is broken, last checked 4/15/2022. |
| Is Public | Yes |
| Language Text | English |