Enhancement of percutaneous absorption of ketoprofen: effect of vehicles and adhesive matrix
Cho, YJ; Choi, HK
| HERO ID | 3039656 |
|---|---|
| In Press | No |
| Year | 1998 |
| Title | Enhancement of percutaneous absorption of ketoprofen: effect of vehicles and adhesive matrix |
| Authors | Cho, YJ; Choi, HK |
| Journal | International Journal of Pharmaceutics |
| Volume | 169 |
| Issue | 1 |
| Page Numbers | 95-104 |
| Abstract | The effects of various vehicles on percutaneous absorption of ketoprofen in a solution formulation and in a pressure-sensitive adhesive (PSA) matrix were evaluated. The permeation rate of ketoprofen across hairless mouse skin was evaluated using a flow-through diffusion cell system at 37 degrees C. The solubility of ketoprofen was determined using the equilibrium solubility method. Among tested vehicles, octanol, ethanol, and propylene glycol (PG)/oleyl alcohol (OA) mixture showed the highest flux of 30 mu g/cm(2) per h from 5 mg/ml solution. However, it was not possible to demonstrate any correlation between the solubility of ketoprofen and its permeation rate, indicating change in the barrier property of the skin and/or carrier mechanism by vehicles used. When the effects of various vehicles on the percutaneous absorption of ketoprofen from acrylic PSA matrix were evaluated, oleic acid showed a slightly higher flux of 2 mu g/cm(2) per h than all other solvents tested. As the concentration of ketoprofen in acrylic PSA matrix increased from 6.3 to 16.7%, the permeation rate also increased almost linearly. The permeation rate of ketoprofen from polyisobutylene (PIB)-type PSA matrix was more than three times higher than that from acrylic PSA matrix. (C) 1998 Elsevier Science B.V. All rights reserved. |
| Doi | 10.1016/S0378-5173(98)00115-X |
| Wosid | WOS:000075092700010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | pressure-sensitive adhesive; transdermal; ketoprofen; vehicle effect; matrix |