Salivary nitrate, nitrite and N-nitroso compounds in patients with cancer of the upper aerodigestive tract
Airoldi, L; Galli, A; Mercato, F; Vago, F; Fanelli, R; Negri, E; La Vecchia, C; Vierucci, S
HERO ID
2985897
Reference Type
Journal Article
Year
1997
Language
English
PMID
| HERO ID | 2985897 |
|---|---|
| In Press | No |
| Year | 1997 |
| Title | Salivary nitrate, nitrite and N-nitroso compounds in patients with cancer of the upper aerodigestive tract |
| Authors | Airoldi, L; Galli, A; Mercato, F; Vago, F; Fanelli, R; Negri, E; La Vecchia, C; Vierucci, S |
| Journal | European Journal of Cancer Prevention |
| Volume | 6 |
| Issue | 4 |
| Page Numbers | 351-356 |
| Abstract | N-nitroso compounds are carcinogens that can be ingested directly or synthesized from nitrites and nitrates. The possible role of N-nitroso compounds in the induction of upper aerodigestive tract tumours was considered in a case-control study conducted in the Valle d'Aosta, an Italian region with a high incidence of these neoplasms. Nitrate, nitrite, labile and stable N-nitroso compounds were analysed in the saliva of 36 patients with cancers of the upper aerodigestive tract and 23 healthy individuals. After allowing for tobacco, salivary nitrate, nitrite and N-nitroso compounds were not associated with an increased risk of upper aerodigestive tract cancers. The odds ratio for continuous units of total N-nitros compounds was 0.99 (95% confidence interval 0.9-1.1). Thus, salivary nitrate, nitrite and N-nitroso compounds might not be suitable markers for the assessment of the risk of cancer of the upper aerodigestive tract, although a role for N-nitroso compounds cannot be excluded. |
| Doi | 10.1097/00008469-199708000-00006 |
| Pmid | 9370097 |
| Wosid | WOS:A1997YD56700006 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | nitrate; nitrite; N-nitroso compounds; upper aerodigestive tract cancers |