Impact of nitrates in drinking water on cancer mortality in Valencia, Spain
Morales-Suárez-Varela, MM; Llopis-Gonzalez, A; Tejerizo-Perez, ML
HERO ID
2955189
Reference Type
Journal Article
Year
1995
Language
English
PMID
| HERO ID | 2955189 |
|---|---|
| In Press | No |
| Year | 1995 |
| Title | Impact of nitrates in drinking water on cancer mortality in Valencia, Spain |
| Authors | Morales-Suárez-Varela, MM; Llopis-Gonzalez, A; Tejerizo-Perez, ML |
| Journal | European Journal of Epidemiology |
| Volume | 11 |
| Issue | 1 |
| Page Numbers | 15-21 |
| Abstract | The concentrations of nitrates in public drinking water in the Mediterranean coastal province of Valencia are not only the highest in Spain but also in the whole of Europe. Intensive agricultural practices involve a traditional and growing use of nitrogen fertilizers. This and the terrain — poorly consolidated and porous in areas — favors the accumulation of nitrates in underground aquifers, thereby perhaps accounting for this contamination. The possible conversion of nitrates to nitrites under certain conditions of gastric achlorhydria, followed by their transformation to nitrosamines — substances known to be carcinogenic in experimental models — has led to a number of epidemiological studies of the possible relationship between high nitrate levels in public drinking water and mortality due to different cancers. The aim of the present study was to analyze the relationship between different levels of exposure to nitrates in the drinking water of the 258 municipalities in the province of Valencia and mortality due to cancer of the stomach, bladder, prostate and colon in this population. The cancer mortality rate was found to rise with increasing exposure to nitrates in the case of gastric cancer in both sexes, and in prostate cancer. These same results were obtained on calculating relative risk for the different age groups associated with the consumption of drinking water containing different levels of nitrates. Thus, in populations with nitrate concentrations in excess of 50 mg/1, relative risk for gastric cancer in the 55–75 years age group was 1.91 and 1.81 for males and females, respectively (p<0.05). In the case of prostate cancer elevated relative risks were also encountered: 1.86 and 1.80 for the 55–75 and over 75 years age groups, respectively. |
| Doi | 10.1007/BF01719941 |
| Pmid | 7489769 |
| Wosid | WOS:A1995RF02400003 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Cancer; Drinking water; Nitrates |