Early fine structural changes in the human liver induced by alcohol
Rubin, E; Lieber, CS
HERO ID
2919664
Reference Type
Journal Article
Year
1967
Language
English
PMID
| HERO ID | 2919664 |
|---|---|
| In Press | No |
| Year | 1967 |
| Title | Early fine structural changes in the human liver induced by alcohol |
| Authors | Rubin, E; Lieber, CS |
| Journal | Gastroenterology |
| Volume | 52 |
| Issue | 1 |
| Page Numbers | 1-13 |
| Abstract | The early ultrastructural changes induced by isocaloric substitution of ethanol for carbohydrate in the livers of 2 human subjects were studied. Mitochondrial alterations and focal cytoplasmic degradation were noted within 1 day of the full dose of ethanol (46 % of total calories), at a time when fat accumulation was minimal. Fatty metamorphosis was prominent within 3 to 10 days of the full dose of ethanol and was associated with alterations of mitochondria, endoplasmic reticulum, autophagic vacuoles, microbodies, and ductular cells. It is concluded that alcohol exerts a direct toxic action on the liver which precedes or is concomitant with fatty metamorphosis. |
| Pmid | 6018368 |
| Url | http://www.gastrojournal.org/article/S0016-5085(67)80093-3/abstract |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |