Redirected to reference 5617416
Prenatal phthalate, perfluoroalkyl acid, and organochlorine exposures and term birth weight in three birth cohorts: multi-pollutant models based on elastic net regression
Lenters, V; Portengen, L; Rignell-Hydbom, A; Jönsson, BA; Lindh, CH; Piersma, AH; Toft, G; Bonde, JP; Heederik, D; Rylander, L; Vermeulen, R
HERO ID
5617416
Reference Type
Journal Article
Year
2016
Language
English
PMID
| HERO ID | 5617416 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Prenatal phthalate, perfluoroalkyl acid, and organochlorine exposures and term birth weight in three birth cohorts: multi-pollutant models based on elastic net regression |
| Authors | Lenters, V; Portengen, L; Rignell-Hydbom, A; Jönsson, BA; Lindh, CH; Piersma, AH; Toft, G; Bonde, JP; Heederik, D; Rylander, L; Vermeulen, R |
| Journal | Environmental Health Perspectives |
| Volume | 124 |
| Issue | 3 |
| Page Numbers | 365-372 |
| Abstract | BACKGROUND: Some legacy and emerging environmental contaminants are suspected risk factors for intrauterine growth restriction. However, the evidence is equivocal, in part due to difficulties in disentangling the effects of mixtures. OBJECTIVES: We assessed associations between multiple correlated biomarkers of environmental exposure and birth weight. METHODS: We evaluated a cohort of 1250 term (≥37 weeks' gestation) singleton infants, born to 513 mothers from Greenland, 180 from Poland, and 557 from Ukraine, who were recruited during antenatal care visits in 2002‒2004. Secondary metabolites of diethylhexyl and diisononyl phthalates (DEHP, DiNP), eight perfluoroalkyl acids, and organochlorines (PCB-153 and p,p'-DDE) were quantifiable in 72‒100% of maternal serum samples. We assessed associations between exposures and term birth weight, adjusting for co-exposures and covariates, including pre-pregnancy body mass index. To identify independent associations, we applied the elastic net penalty to linear regression models. RESULTS: Two phthalate metabolites (MEHHP, MOiNP), perfluorooctanoate (PFOA), and p,p'-DDE were most consistently predictive of term birth weight based on elastic net penalty regression. In an adjusted, unpenalized regression model of the four exposures, 2-SD increases in natural log-transformed MEHHP, PFOA, and p,p'-DDE were associated with lower birth weight: -87 g (95% CI: -137, -340 per 1.70 ng/mL), -43 g (95% CI: -108, 23; per 1.18 ng/mL), and -135 g (95% CI: -192, -78 per 1.82 ng/g lipid), respectively; while MOiNP was associated with higher birth weight (46 g; 95% CI: -5, 97 per 2.22 ng/mL). CONCLUSIONS: This study suggests that several of the environmental contaminants, belonging to three chemical classes, may be independently associated with impaired fetal growth. These results warrant follow-up in other cohorts. |
| Doi | 10.1289/ehp.1408933 |
| Pmid | 26115335 |
| Wosid | WOS:000371442500024 |
| Url | https://www.proquest.com/scholarly-journals/prenatal-phthalate-perfluoroalkyl-acid/docview/1846401824/se-2?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Environmental Health Perspectives (Online) ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | Toxicology Abstracts; Pollution Abstracts; Environment Abstracts; MED, Ukraine; Insecticides; Infants; Gestation; Risk factors; Chemical pollution; Body mass index; Secondary metabolites; Metabolites; Organochlorine compounds; Bioindicators; Nitrous oxide; Prenatal experience; AN, Greenland; Phthalic acid; biomarkers; Fetuses; diisononyl phthalate; perfluorooctanoic acid; Regression analysis; Phthalates; Contaminants; Birth weight; ENA 02:Toxicology & Environmental Safety; X 24330:Agrochemicals; P 6000:TOXICOLOGY AND HEALTH |
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