Dichloromethane inhalation, carboxyhemoglobin concentrations, and drug metabolizing enzymes in rabbits
Roth, RP; Drew, RT; Lo, RJ; Fouts, JR
HERO ID
29063
Reference Type
Journal Article
Year
1975
Language
English
PMID
| HERO ID | 29063 |
|---|---|
| In Press | No |
| Year | 1975 |
| Title | Dichloromethane inhalation, carboxyhemoglobin concentrations, and drug metabolizing enzymes in rabbits |
| Authors | Roth, RP; Drew, RT; Lo, RJ; Fouts, JR |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 33 |
| Issue | 3 |
| Page Numbers | 427-437 |
| Abstract | The relationship between inhaled dichloromethane (DCM) and percentage of carboxyhemoglobin (% COHb) in blood has been investigated in rabbits. After a single 20-min exposure to DCM, % COHb rose to a maximum within 2–3 hr and usually declined to basal values within 8 hr. The maximum COHb concentration and the time to reach that value were DCM concentration-dependent. In rabbits given a 4-hr exposure to DCM, % COHb increased over the first 2–3 hr, reaching a peak by about 4 hr with a return to basal levels within 24 hr. Studies were carried out to determine whether treatment with modifiers of hepatic mixed-function oxidase changed the % COHb response after DCM exposure. Of the compounds investigated, only CCl4 and phenobarbital altered % COHb resulting from DCM inhalation. As expected, CCl4, a potent hepatotoxin, reduced the % COHb resulting from DCM inhalation. Contrary to expectations phenobarbital also lowered the COHb response from DCM inhalation although the decrease was not as marked as that caused by CCl4. |
| Doi | 10.1016/0041-008X(75)90069-1 |
| Pmid | 1188941 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Toxicol. Appl. Pharmacol. 33: 427-437. |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |