Human and canine exposures to methylene chloride vapor
Divincenzo, GD; Yanno, FJ; Astill, BD
HERO ID
29028
Reference Type
Journal Article
Year
1972
Language
English
PMID
| HERO ID | 29028 |
|---|---|
| In Press | No |
| Year | 1972 |
| Title | Human and canine exposures to methylene chloride vapor |
| Authors | Divincenzo, GD; Yanno, FJ; Astill, BD |
| Journal | American Industrial Hygiene Association Journal |
| Volume | 33 |
| Issue | 3 |
| Page Numbers | 125-135 |
| Abstract | HEEP COPYRIGHT: BIOL ABS. Well-controlled experimental exposures to methylene chloride vapor lasting for 2 or 4 hr were performed in human beings and dogs. The exposure concentrations ranged from 100 to 1000 ppm in the dogs and from 100 to 200 ppm in man. Serial breath and blood curves from both species were directly proportional to the magnitude of exposure. The average 24-hr urinary excretions of methylene chloride for the 100- and 200- ppm exposures in man were approximately 23 mug and 82 mug, respectively. During comparable exposures, the dog absorbed substantially more methylene chloride vapor than man. Prolonging the exposure from 2 to 4 hr did not result in a substantial increase in solvent absorption. It is possible to make accurate extrapolations to human exposures from animal experiments provided the appropriate attention is given to factors such as the exposure duration, the time of collection after the exposure, the extent of metabolic involvement and kinetic parameters. In such extrapolations, it is sometimes necessary to correct the experimental die-away curves because of changes in muscular exercise during the exposure. |
| Doi | 10.1080/0002889728506622 |
| Pmid | 5074669 |
| Wosid | WOS:A1972N604200001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Am. Ind. Hyg. Assoc. J. 33: 125-135. |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |