Formal synthesis of (±)-morphine
Li, J; Liu, GL; Zhao, XH; Du, JY; Qu, H; Chu, WD; Ding, M; Jin, CY; Wei, MX; Fan, CA
| HERO ID | 2901808 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Formal synthesis of (±)-morphine |
| Authors | Li, J; Liu, GL; Zhao, XH; Du, JY; Qu, H; Chu, WD; Ding, M; Jin, CY; Wei, MX; Fan, CA |
| Journal | Chemistry - An Asian Journal |
| Volume | 8 |
| Issue | 6 |
| Page Numbers | 1105-1109 |
| Abstract | The pain ends here: A novel synthetic strategy for the construction of (±)-morphine rings B and E was developed, in which SmI2 -promoted reductive coupling/desulfurization and tandem alcoholysis/oxa-Michael addition featured as the key steps for the assembly of the C9-C14 and C5-O bonds, respectively. Asymmetric tandem alcoholysis/oxa-Michael addition was also feasible for the enantiocontrolled synthesis of morphine. |
| Doi | 10.1002/asia.201300139 |
| Pmid | 23509056 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |