(±)-Pestalachloride D, an antibacterial racemate of chlorinated benzophenone derivative from a soft coral-derived fungus Pestalotiopsis sp
Wei, MY; Li, D; Shao, CL; Deng, DS; Wang, CY
HERO ID
2901758
Reference Type
Journal Article
Year
2013
Language
English
PMID
| HERO ID | 2901758 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | (±)-Pestalachloride D, an antibacterial racemate of chlorinated benzophenone derivative from a soft coral-derived fungus Pestalotiopsis sp |
| Authors | Wei, MY; Li, D; Shao, CL; Deng, DS; Wang, CY |
| Journal | Marine Drugs |
| Volume | 11 |
| Issue | 4 |
| Page Numbers | 1050-1060 |
| Abstract | A new antibacterial chlorinated benzophenone derivative, (±)-pestalachloride D (1), along with a related analog, (±)-pestalachloride C (2), was recently isolated from the marine-derived fungus Pestalotiopsis sp. isolated from a soft coral Sarcophyton sp. collected from Yongxing Island in the South China Sea. Both chiral HPLC analysis and single-crystal X-ray data indicated that 1 is a racemic mixture. Interestingly, 1 did not exhibit any effect in the zebrafish embryo teratogenicity assay, while 2 led to abnormal growth. The potential impact on zebrafish embryo growth is discussed based on their crystal structures. The main difference of crystal structures between 1 and 2 is that the six-member non-aromatic ring (O4, C10, C9, C8, C2', and C3') in 1 exhibits a distorted chair conformation, while 2 shows a distorted boat conformation. Moreover, compounds 1 and 2 both exhibited moderate antibacterial activity. |
| Doi | 10.3390/md11041050 |
| Pmid | 23538869 |
| Wosid | WOS:000318018700005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |