Formation of a pseudo-β-hairpin motif utilizing the Ant-Pro reverse turn: consequences of stereochemical reordering
Nair, RV; Kotmale, AS; Dhokale, SA; Gawade, RL; Puranik, VG; Rajamohanan, PR; Sanjayan, GJ
HERO ID
2899398
Reference Type
Journal Article
Year
2014
Language
English
PMID
| HERO ID | 2899398 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Formation of a pseudo-β-hairpin motif utilizing the Ant-Pro reverse turn: consequences of stereochemical reordering |
| Authors | Nair, RV; Kotmale, AS; Dhokale, SA; Gawade, RL; Puranik, VG; Rajamohanan, PR; Sanjayan, GJ |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 12 |
| Issue | 5 |
| Page Numbers | 774-782 |
| Abstract | Herein, we report a special case of pseudo-β-hairpin formation by tetrapetide sequences featuring a two-membered Ant-Pro dipeptide motif (Ant = anthranilic acid and Pro = proline) at the loop region. These folded structures uniquely feature the presence of C9- and C17-H-bonding patterns at reverse turn and interstrand regions, respectively. Their hairpin nucleation and folding propensities have been expounded using solution and solid state studies of distinct stereochemically altered sequences. |
| Doi | 10.1039/c3ob42016g |
| Pmid | 24306101 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |