Antinociceptive effect of some biuret derivatives on formalin test in mice
Adibpour, N; Poornajjari, A; Khodayar, MJ; Rezaee, S
HERO ID
2899285
Reference Type
Journal Article
Year
2014
Language
English
PMID
| HERO ID | 2899285 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Antinociceptive effect of some biuret derivatives on formalin test in mice |
| Authors | Adibpour, N; Poornajjari, A; Khodayar, MJ; Rezaee, S |
| Volume | 4 |
| Issue | 2 |
| Page Numbers | 179-183 |
| Abstract | <strong>PURPOSE: </strong>The current study was designed to investigate the antinociceptive effects of several biuret derivatives with N, N`-diphenyl, N-phenyl-N`-alkylphenyl, N,N`-bis alkylphenyl, 2-methylquinoline-4-yl, benzo[d]thiazol-2-ylthio and (1-phenyl-1H-tetrazol-5-yl)thio substituents on the formalin-evoked pain in mice.<br /><br /><strong>METHODS: </strong>Antinociceptive activity of the nine biurets derivatives were assessed at different doses in mice using formalin test and the results were compared with those of indomethacin(20 mg/kg) and vehicle of the compounds. Area under the pain score curve against time (AUEC) up to 60 minutes was used as the measure of pain behavior.<br /><br /><strong>RESULTS: </strong>A rather good analgesic effect was seen for most of the tested biuret derivatives. Significant reduction in median AUEC0-5 minutes was observed at the doses of 50 and 25 mg/kg for biurets with either benzyl and 2-methylquinoline-4-yl (C8) or phenylethyl and benzo[d]thiazol-2-ylthio(C9) moieties, respectively(p-value<0.0044). Antinociceptive activities of compound C7 (with bis phenylropyl substituent), C8 and C9 during the late phase of formaldehyde-induced pain were comparable to that of indomethacin.<br /><br /><strong>CONCLUSION: </strong>Unlike indomethacin, the tested biuret compounds are able to induce antinociception in both phases of formalin test and could be considered comparable to indomethacin at the selected doses. |
| Doi | 10.5681/apb.2014.026 |
| Pmid | 24511482 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Advanced pharmaceutical bulletin ISSN: 2228-5881 |
| Is Public | Yes |
| Language Text | English |