Environmentally Friendly and Highly Efficient Co(OAc)(2)-Catalyzed Aerobic Oxidation to Access 2,6-Di-Electron-Donating Group Substituted 4-Hydroxybenzaldehydes
Jiang, JAn; Du, JiaLei; Zhang, ZNan; Zhai, JJ; Ji, YaFei
| HERO ID | 2896926 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Environmentally Friendly and Highly Efficient Co(OAc)(2)-Catalyzed Aerobic Oxidation to Access 2,6-Di-Electron-Donating Group Substituted 4-Hydroxybenzaldehydes |
| Authors | Jiang, JAn; Du, JiaLei; Zhang, ZNan; Zhai, JJ; Ji, YaFei |
| Journal | Synthetic Communications |
| Volume | 44 |
| Issue | 10 |
| Page Numbers | 1430-1440 |
| Abstract | A highly efficient and green aerobic oxidation has been developed for selectively preparing a series of valuable 2,6-dialkyl-, dialkoxyl-, and alkoxylalkyl-substituted 4-hydroxybenzaldehydes from corresponding 4-cresols in good to excellent yields, using a catalytic system of Co(OAc)(2)center dot 4H(2)O (1.0mol%)-NaOH (1.0 equiv)-O-2 (1.0atm) in aqueous ethylene glycol (EG/H2O=20/1, v/v) at 50 degrees C. Furthermore, a plausible mechanism was proposed for the direct oxyfunctionalization of the aromatic methyl group into the aldehyde group. |
| Doi | 10.1080/00397911.2013.813052 |
| Wosid | WOS:000335119700005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | oxyfunctionalization; ethylene glycol; Aerobic oxidation; 4-hydroxybenzaldehydes; Co(OAc)2 |