In vitro and in vivo hepatoprotective and antioxidant activity of ethanolic extract from Meconopsis integrifolia (Maxim.) Franch
Zhou, G; Chen, Y; Liu, S; Yao, X; Wang, Y
| HERO ID | 2866794 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | In vitro and in vivo hepatoprotective and antioxidant activity of ethanolic extract from Meconopsis integrifolia (Maxim.) Franch |
| Authors | Zhou, G; Chen, Y; Liu, S; Yao, X; Wang, Y |
| Journal | Journal of Ethnopharmacology |
| Volume | 148 |
| Issue | 2 |
| Page Numbers | 664-670 |
| Abstract | <strong>ETHNOPHARMACOLOGICAL RELEVANCE: </strong>Meconopsis integrifolia (Maxim.) Franch is a high mountain endemic species used as a traditional Tibetan and Mongolian herb to treat hepatitis, pneumonia, and edema. This study aims to investigate the hepatoprotective and antioxidant effects of Meconopsis integrifolia ethanolic extract (MIE) in vitro and in vivo.<br /><br /><strong>MATERIALS AND METHODS: </strong>The in vitro antioxidant property of MIE was investigated by employing various established systems. Rats with carbon tetrachloride (CCl4)-induced liver injury were used to assess the hepatoprotective and antioxidant effect of MIE in vivo. The level or activity of alkaline phosphatase (ALP), glutamate pyruvate transaminase (ALT), aspartate aminotransferase (AST), and total bilirubin (TB) in the blood serum and thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) in the liver and kidney of the rats were assayed using standard procedures.<br /><br /><strong>RESULTS: </strong>MIE exhibited strong antioxidant ability in vitro. In the rats with CCl4-induced liver injury, the groups treated with MIE and silymarin showed significantly lower levels of ALT, AST, ALP, and TB. MIE demonstrated good antioxidant activities in both the liver and kidney of the rats in vivo.<br /><br /><strong>CONCLUSIONS: </strong>MIE exhibits excellent hepatoprotective effects and antioxidant activities in vitro and in vivo, supporting the traditional use of Meconopsis integrifolia in the treatment of hepatitis. |
| Doi | 10.1016/j.jep.2013.05.027 |
| Pmid | 23707208 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |