Geographic variation in the association between ambient fine particulate matter (PM2.5) and term low birth weight in the United States
Hao, Y; Srosnider, H; Balluz, L; Qualters, JR
HERO ID
2857122
Reference Type
Journal Article
Year
2015
Language
English
PMID
| HERO ID | 2857122 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Geographic variation in the association between ambient fine particulate matter (PM2.5) and term low birth weight in the United States |
| Authors | Hao, Y; Srosnider, H; Balluz, L; Qualters, JR |
| Journal | Environmental Health Perspectives |
| Volume | 124 |
| Issue | 2 |
| Page Numbers | 250-255 |
| Abstract | BACKGROUND: Studies on the association between prenatal exposure to fine particulate matter with ≤ 2.5 micrometers in aerodynamic diameter (PM2.5) and term low birth weight (LBW) have resulted in inconsistent findings. Most studies were conducted in snapshots of small geographic areas and no national study exists. OBJECTIVES: We investigated geographic variation in the associations between ambient PM2.5 during pregnancy and term LBW in the contiguous United States (US). METHODS: 3,389,450 term singleton births in 2002 (37 - 44 weeks gestational age and birth weight of 1,000g - 5,500g) were linked to daily PM2.5 via imputed birth days. We generated average daily PM2.5 during the entire pregnancy and each trimester. Multilevel logistic regression models with county-level random effects were used to evaluate the associations between term LBW and PM2.5 during pregnancy. RESULTS: Without adjusting for covariates, the odds of term LBW increased 2% (OR=1.02; 95% CI: 1.00, 1.03) for every 5 µg/m3 increase in PM2.5 exposure during the second trimester only, which remained unchanged after adjusting for county-level poverty (OR=1.02; 95% CI: 1.01, 1.04). The odds did change to null after adjusting for individual-level predictors (OR=1.00; 95% CI: 0.99, 1.02). Multilevel analyses, stratified by census division, revealed significant positive associations of term LBW and PM2.5 exposure (during the entire pregnancy or a specific trimester) in three census divisions: Middle Atlantic, East North Central, and West North Central, and significant negative association in the Mountain division. CONCLUSIONS: Our study provided additional evidence on the associations between PM2.5 exposure during pregnancy and term LBW from a national perspective. The magnitude and direction of the estimated associations between PM2.5 exposure and term LBW varied by geographic locations in the US. |
| Doi | 10.1289/ehp.1408798 |
| Pmid | 26046626 |
| Wosid | WOS:000369337900019 |
| Url | http://ehp.niehs.nih.gov/wp-content/uploads/advpub/2015/6/ehp.1408798.acco.pdf |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
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