Reduction of spinal PGE(2) concentrations prevents swim stress-induced thermal hyperalgesia
Guevara, C; Fernandez, A; Cardenas, R; Suarez-Roca, H
| HERO ID | 2841378 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Reduction of spinal PGE(2) concentrations prevents swim stress-induced thermal hyperalgesia |
| Authors | Guevara, C; Fernandez, A; Cardenas, R; Suarez-Roca, H |
| Journal | Neuroscience Letters |
| Volume | 591 |
| Page Numbers | 110-114 |
| Abstract | We evaluated the association between spinal PGE(2) and thermal hyperalgesia following repeated stress. Thermal nociception was determined in male Sprague-Dawley rats using the hot-plate test, before and after forced-swimming; non-conditioned rats served as controls. Animals were pretreated with ketoprofen or meloxicam, preferential COX-1 and COX-2 inhibitors, respectively. After the second hot-plate test, we measured serum corticosterone (stress marker), and lumbar spinal PGE(2) (neuroinflammation marker) under peripheral inflammation (1% formalin plantar injection). Stressed rats displayed response latencies 40% shorter and inflammatory spinal PGE2 levels 95% higher than controls. Pretreatment with ketoprofen or meloxicam prevented hyperalgesia and elevation of spinal PGE(2), increasing the escape behavior time during forced swimming 95% respect to saline-treated rats. Corticosterone levels in stressed rats were 97% higher than controls; COX inhibitors reduced them by 84%. PGE(2) could participate in stress-induced hyperalgesia, learned helplessness, and corticosterone production, supporting the use of non-steroidal anti-inflammatory drugs (NSAIDs) for persistent pain associated with chronic stress and depression. (C) 2015 Elsevier Ireland Ltd. All rights reserved. |
| Doi | 10.1016/j.neulet.2015.02.035 |
| Pmid | 25703222 |
| Wosid | WOS:000351786700021 |
| Url | http://dx.doi.org/10.1016/j.neulet.2015.02.035 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Thermal hyperalgesia; Forced-swimming; Cyclooxygenase; Prostaglandin E-2; Ketoprofen; Meloxicam; Corticosterone |