Studies of Toxicity and Enzyme Activity Resulting from Interaction between Chlorinated Hydrocarbon and Carbamate Insecticides
Williams, CH; Casterline JL Jr; Jacobson, KH
| HERO ID | 2826119 |
|---|---|
| In Press | No |
| Year | 1967 |
| Title | Studies of Toxicity and Enzyme Activity Resulting from Interaction between Chlorinated Hydrocarbon and Carbamate Insecticides |
| Authors | Williams, CH; Casterline JL Jr; Jacobson, KH |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 11 |
| Issue | 2 |
| Page Numbers | 302-307 |
| Abstract | The effect of aldrin (309002) and chlordane (57749) pretreatment on the acute oral toxicity of Banol (671045) and Mobam (1079330) was studied in the rat. Female Osborne-Mendel-rats were given intraperitoneal injections of chlordane and aldrin 8 days prior to exposure by oral intubation to Banol or Mobam. The acute oral toxicity of Banol was markedly decreased and that of Mobam was slightly decreased by pretreatment of rats with chlordane or aldrin. An increase in serum and liver aliesterase (AliE) activities was caused by aldrin and chlordane but there was no change in liver and brain cholinesterase (ChE) activities. Mobam inhibited the activities of liver and brain ChE and liver and serum AliE. In aldrin pretreated rats, Banol inhibited serum AliE more, liver AliE the same, and brain and liver ChE slightly less than when administered alone. In aldrin pretreated rats Mobam did not change liver or serum AliE activities, but did decrease activities of brain and liver ChE less than when given alone. Aldrin protected against Banol as well as chlordane did, but the enzyme activities were different. Protection against Mobam was less effective, but the effects on enzyme systems were roughly paralleled by those produced by Banol. |
| Doi | 10.1016/0041-008X(67)90073-7 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0043153884&doi=10.1016%2f0041-008X%2867%2990073-7&partnerID=40&md5=c9c3e544c60ebfff851ab974c47223da |
| Is Public | Yes |
| Language Text | English |