Long term in vitro biostability of segmented polyisobutylene-based thermoplastic polyurethanes
Cozzens, D; Ojha, U; Kulkarni, P; Faust, R; Desai, S
| HERO ID | 2623192 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | Long term in vitro biostability of segmented polyisobutylene-based thermoplastic polyurethanes |
| Authors | Cozzens, D; Ojha, U; Kulkarni, P; Faust, R; Desai, S |
| Journal | Journal of Biomedical Materials Research. Part A |
| Volume | 95A |
| Issue | 3 |
| Page Numbers | 774-782 |
| Abstract | Long term in vitro biostability of thermoplastic polyurethanes (TPUs) containing mixed polyisobutylene (PIB)/poly(tetramethylene oxide) (PTMO) soft segment was studied under accelerated conditions in 20% H(2)O(2) solution containing 0.1M CoCl(2) at 50 degrees C to predict resistance to metal ion oxidative degradation (MIO) in vivo. The PM-based TPUs showed significant oxidative stability as compared to the commercial controls Pellethane (TM) 2363-55D and 2363-80A. After 12 weeks in vitro the PIB-PTMO TPUs with 10-20% PTMO in the soft segment showed 6-10% weight loss whereas the Pellethane (TM) TPUs degraded completely in about 9 weeks. Attenuated total reflectance Fourier transform infrared spectroscopy confirmed the degradation of Pellethane (TM) samples via MIO by the loss of the similar to 1110 cm(-1) aliphatic C-O-C stretching peak height attributed to chain scission, and the appearance of a new peak at similar to 1174 cm(-1) attributed to crosslinking. No such changes were apparent in the spectra of the PIB-based TPUs. The PO-based TPUs exhibited 10-30% drop in tensile strength compared to 100% for the Pellethane (TM) TPUs after 12 weeks. The molecular weight of the PIB-based TPUs decreased slightly (10-15%) at 12 weeks. The Pellethane (TM) TPUs showed a dramatic decrease in M(n) and an increase in low molecular weight degradation product. Scanning electron microscopy (SEM) showed severe cracking in the Pellethane (TM) samples after 2 weeks, whereas the PIB-based TPUs exhibited a continuous surface morphology. The weight loss, tensile, and SEM data correlate well with each other and indicate excellent biostability of these materials. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 95A: 774-782, 2010. |
| Doi | 10.1002/jbm.a.32897 |
| Pmid | 20725977 |
| Wosid | WOS:000283959800014 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | biostability; polyurethane; polyisobutylene; metal ion oxidation; in vitro |