[Experimental rationale for carcinogenic risk of asbestos cement industry and its products]
Pylev, DN; Smirnova, OV; Vasil'eva, LA; Khrustalev, SA; Vezentsev, AI; Gudkova, EA; Naumova, LN
| HERO ID | 2576934 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | [Experimental rationale for carcinogenic risk of asbestos cement industry and its products] |
| Authors | Pylev, DN; Smirnova, OV; Vasil'eva, LA; Khrustalev, SA; Vezentsev, AI; Gudkova, EA; Naumova, LN |
| Journal | Gigiena i Sanitariya |
| Issue | 6 |
| Page Numbers | 61-65 |
| Abstract | During intraperitoneal administration of dispersiveness-comparable chrysotile or asbestos cement fibers to rats (20 mg thrice), mesotheliomas were found in 45.1 and 7.7% of cases respectively. Asbestos cement dust induced tumors in 2.5% of cases, which is of biological importance. Cement or freeze asbestos destruction cement dust failed to cause tumors. The latter were not detected in a control group receiving physiological saline. Asbestos cement fibers and fascicles are covered by a cement matrix. Fiber amorphization gradually occurs. In lung tissue, there may be destruction of the cement coat of fascicles and release of native chrysotile fibers that are carcinogenic. |
| Pmid | 21381365 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | Russian |