Effects of methylmercuric chloride on the progeny of mice and rats treated before or during gestation
Khera, KS; Tabacova, SA
HERO ID
2533090
Reference Type
Journal Article
Year
1973
Language
English
PMID
| HERO ID | 2533090 |
|---|---|
| In Press | No |
| Year | 1973 |
| Title | Effects of methylmercuric chloride on the progeny of mice and rats treated before or during gestation |
| Authors | Khera, KS; Tabacova, SA |
| Journal | Food and Cosmetics Toxicology |
| Volume | 11 |
| Issue | 2 |
| Page Numbers | 245-254 |
| Abstract | Pregnant mice intubated with mercury as CH3HgCl in doses of 0, 0·1, 1 or 5 mg Hg/kg/day from day 6 to day 17 of pregnancy, inclusive, were allowed to litter. Doses of 5 mg/kg/day caused 100% stillbirths or neonatal deaths but no apparent maternal toxicity. Doses of 1 mg/kg/day induced a transitory inhibition of cerebellar cellular migration from the external granular layer and depressed reactions of oxidative enzymes. These histological changes were not associated with any obvious adverse clinical effects and were not seen at lower doses. Weanling female rats were fed diets containing levels of 0, 0·002, 0·01, 0·05 or 0·25 mg Hg (as CH3HgCl)/kg/day and were mated at maturity with untreated males. Some dams were killed at term and others were allowed to litter. No adverse effect was apparent in foetuses taken at term from dams given up to 0·25 mg Hg/kg/day. Postnatally, developmental defects of undetermined aetiology were observed in the eyelids in animals from all test groups and the controls. These were associated with histological changes in the harderian gland, the exorbital lachrymal gland and the parotid salivary gland. The incidence of ocular defects was dose-related and increased significantly in the group on 0·25 mg Hg/kg/day. Rats with ocular defects were killed and at weaning the remaining offspring from each group were distributed into two sub-groups, one of which was given the appropriate methylmercury-containing diet while the other was reared on control feed. Adult mating within each sub-group revealed that continuation or cessation of treatment with methylmercury had no effect on the production of corpora lutea or on reproductive performance. |
| Doi | 10.1016/S0015-6264(73)80491-2 |
| Pmid | 4197780 |
| Wosid | WOS:A1973P469100008 |
| Url | http://dx.doi.org/10.1016/S0015-6264(73)80491-2 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Peer Review | No |
| Relationship(s) |
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