Analgesic properties of melatonin and its possible therapeutic application in pain syndromes
Zan, RS; Rolinski, Z; Kowalski, CJ; Burmanczuk, A
| HERO ID | 2454063 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Analgesic properties of melatonin and its possible therapeutic application in pain syndromes |
| Authors | Zan, RS; Rolinski, Z; Kowalski, CJ; Burmanczuk, A |
| Journal | Medycyna Weterynaryjna |
| Volume | 70 |
| Issue | 6 |
| Page Numbers | 336-341 |
| Abstract | The aim of this paper was to analyze the role of melatonin (MLT) in acute and chronic pain states, and to describe the profile of melatonin as a potential analgesic. Melatonin (N-acetyl-5-methoxytryptamine) is the main pineal neurohormone involved in many physiological and endocrine functions, as well as in behavioral states in humans and animals. One may mention functions such as the regulation of circadian rhythm, sleep, mood, processes of reproduction, immune response, and aging. The distribution of MLT receptors in the spinal cord and in many other regions of the brain associated with receiving pain impulses, indirectly confirms the possible involvement of indoleamine in the phenomenon of pain. In clinical studies, MLT has been shown to have analgesic benefits in patients with acute and chronic pain (migraine, fibromyalgia, irritable bowel syndrome). In preliminary studies, it has also been suggested that MLT may have potent analgesic and anxiolytic properties in the perioperative period. |
| Wosid | WOS:000336708500004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | melatonin; pain syndrome; antinociceptive effect; animals |