CHARACTERIZATION OF THE BRONCHOALVEOLAR CELLULAR-RESPONSE IN EXPERIMENTAL ASBESTOSIS - DIFFERENT REACTIONS DEPENDING ON THE FIBROGENIC POTENTIAL
Lemaire, I
| HERO ID | 2451061 |
|---|---|
| In Press | No |
| Year | 1985 |
| Title | CHARACTERIZATION OF THE BRONCHOALVEOLAR CELLULAR-RESPONSE IN EXPERIMENTAL ASBESTOSIS - DIFFERENT REACTIONS DEPENDING ON THE FIBROGENIC POTENTIAL |
| Authors | Lemaire, I |
| Journal | American Review of Respiratory Disease |
| Volume | 131 |
| Issue | 1 |
| Page Numbers | 144-149 |
| Abstract | A comparison was made of progressive bronchoalveolar cellular response to two chrysotile (12001295) asbestos samples with different fibrogenic potential. Male Wistar-rats were given single intratracheal injections of saline, UICC chrysotile-B asbestos, or very short 4T30 chrysotile fibers. At various intervals after instillation, bronchoalveolar lavage (BAL) was performed. Significant increases were noted in inflammatory cells in response to the asbestos treatment. This effect persisted for a longer period of time in animals treated with chrysotile-B. The finding of mitotic figures in BAL fluid suggests that macrophage replication may contribute in part to this response. After injection of long chrysotile fibers, causing fibrotic lesions in 7 days, polymorphonuclear leukocytes (PMN) appeared as quickly as day one and persisted through day seven. Multinucleated cells (MGC) were present in lavage fluid from day seven to day 21. Most of these cells were binucleated and none had more than three nuclei. Exposure to very short chrysotile fibers caused only a transient influx of PMN on day one. A significant increase in MGC was noted by day seven and persisted through day 21. No fibrosis was apparent by day 21. Many cells had three nuclei or more. Giant cells were predominantly of the foreign body type. MGC of the Langhans type were also present. The author concludes that bronchoalveolar cell alterations correlated with differences in lung injury, and suggests a possible role for PMN and MGC in modulating macrophage function and lung response to injury. |
| Pmid | 3966702 |
| Wosid | WOS:A1985TZ98800031 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | effects on; relationship; leukocytes (polymorphonuclear); fibrils; asbestos; Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts; X 24154:Pathology; P 6000:TOXICOLOGY AND HEALTH; H SM10.24:PULMONARY DISEASES |