Urinary phthalate metabolite associations with biomarkers of inflammation and oxidative stress across pregnancy in puerto rico
Ferguson, KK; Cantonwine, DE; Rivera-González, LO; Loch-Caruso, R; Mukherjee, B; Del Toro, LVA; Jiménez-Vélez, B; Calafat, AM; Ye, X; Alshawabkeh, AN; Cordero, JF; Meeker, JD
HERO ID
2345963
Reference Type
Journal Article
Year
2014
Language
English
PMID
| HERO ID | 2345963 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Urinary phthalate metabolite associations with biomarkers of inflammation and oxidative stress across pregnancy in puerto rico |
| Authors | Ferguson, KK; Cantonwine, DE; Rivera-González, LO; Loch-Caruso, R; Mukherjee, B; Del Toro, LVA; Jiménez-Vélez, B; Calafat, AM; Ye, X; Alshawabkeh, AN; Cordero, JF; Meeker, JD |
| Journal | Environmental Science & Technology |
| Volume | 48 |
| Issue | 12 |
| Page Numbers | 7018-7025 |
| Abstract | Phthalate exposure during pregnancy has been linked to adverse birth outcomes such as preterm birth, and inflammation and oxidative stress may mediate these relationships. In a prospective cohort study of pregnant women recruited early in gestation in Northern Puerto Rico, we investigated the associations between urinary phthalate metabolites and biomarkers of inflammation, including C-reactive protein, IL-1β, IL-6, IL-10, and TNF-α, and oxidative stress, including 8-hydroxydeoxyguanosine (OHdG) and 8-isoprostane. Inflammation biomarkers were measured in plasma twice during pregnancy (N = 215 measurements, N = 120 subjects), and oxidative stress biomarkers in urine were measured three times (N = 148 measurements, N = 54 subjects) per woman. In adjusted linear mixed models, metabolites of di-2-ethylhexyl phthalate (DEHP) were associated with increased IL-6 and IL-10 but relationships were generally not statistically significant. All phthalates were associated with increases in oxidative stress markers. Relationships with OHdG were significant for DEHP metabolites as well as mono-n-butyl phthalate (MBP) and monoiso-butyl phthalate (MiBP). For 8-isoprostane, associations with nearly all phthalates were statistically significant and the largest effect estimates were observed for MBP and MiBP (49-50% increase in 8-isoprostane with an interquartile range increase in metabolite concentration). These relationships suggest a possible mechanism for phthalate action that may be relevant to a number of adverse health outcomes. |
| Doi | 10.1021/es502076j |
| Pmid | 24845688 |
| Wosid | WOS:000337646000060 |
| Url | https://search.proquest.com/docview/1540588276?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Environmental Studies; Polyethylene terephthalate; Oxidative stress; Human exposure; Effects; Pregnancy; Biomarkers; Puerto Rico |
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