Anti proliferative effect of arsenic, cadmium and lead on human placental chorion cells
Ahmad, A; Shah, A; Shakoori, AR
HERO ID
2345745
Reference Type
Journal Article
Year
2014
Language
English
| HERO ID | 2345745 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Anti proliferative effect of arsenic, cadmium and lead on human placental chorion cells |
| Authors | Ahmad, A; Shah, A; Shakoori, AR |
| Journal | Pakistan Journal of Zoology |
| Volume | 46 |
| Issue | 2 |
| Page Numbers | 561-566 |
| Abstract | Heavy metals present in environment can effect human health in different ways. These heavy metals can even cross placenta and cause harm to the developing fetus. In the present study the anti-proliferative effects of arsenic, cadmium and lead were studied on human placental chorion cells (PCCs). The cells were isolated by explant method from placental tissue. Anti-proliferative effects of arsenic, cadmium and lead were tested by neutral red uptake assay. Both arsenic and cadmium proved to be very toxic for PCCs. There was marked decrease in cell proliferation when cells were exposed to different metal concentrations for 24 h. There was reduction in proliferation of cells on exposure to lead but the effect of lead on PCCs was not as severe as that of arsenic and cadmium. It is concluded that arsenic, cadmium and lead are toxic to PCCs and hence there is a need to adopt proper measures to reduce the exposure of animals and human. |
| Wosid | WOS:000335719100033 |
| Url | http://zsp.com.pk/vol-46[2]%20.html |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Placental chorion cells; heavy metals; proliferation; cytotoxicity |