Spectrophotometric and FT-IR studies of interaction of narcotic drugs (morphine, codeine and thebaine) with acceptors (HQ, BQ, NQ, PA, o-Chlo, DNB), their thermodynamics and determination of the vertical ionization potentials of the drugs
Kuila, DK; Lahiri, SC
| HERO ID | 2344117 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | Spectrophotometric and FT-IR studies of interaction of narcotic drugs (morphine, codeine and thebaine) with acceptors (HQ, BQ, NQ, PA, o-Chlo, DNB), their thermodynamics and determination of the vertical ionization potentials of the drugs |
| Authors | Kuila, DK; Lahiri, SC |
| Journal | Journal of the Indian Chemical Society |
| Volume | 87 |
| Issue | 5 |
| Page Numbers | 557-572 |
| Abstract | Morphine, codeine and thebaine formed charge transfer complexes with acceptors like hydroquinone, benzoquinone, naphthaquinone, picric acid, chloranil and dinitrobenzene as evidenced from the shifting of absorption maxima and change in optical densities in the UV regions. The evidence of complex formation was observed from the optical densities of the complex in the visible region when D>>A and where D and A do not absorb. The evidence of complex formation was also adduced from FT-IR measurements for morphine + naphthaquinone, codeine + naphthaquinone and thebaine + naphthaquinone complexes. The formations of CT complexes with those acceptors arc confirmed from the plots of hvCT against IDV (vertical ionization potential) of the drugs. From the values CT transition energies, the vertical ionization potentials (IDV) of morphine, codeine and thebaine were estimated to be 7.228 ± 0.396, 7.236 ± 0.399 and 7.233 ± 0.405 eV respectively. The almost equal values are due to structural similarities of the drugs. The degrees of overlap in the ground state of the complexes were also calculated. The association constants and thermodynamics of the complexes (e.g. ΔG0, ΔH0 and ΔS0) were determined spectrophotometrically from the o.d measurements at 298, 303, 306 and 310 K using D and A in stoichiometric ratios, a condition necessary for the accurate determination of the association constants. The complexes are fairly stable. |
| Wosid | WOS:000278925800004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953965861&partnerID=40&md5=ea9311099e4e3d01be72b554974f753e |
| Is Public | Yes |
| Language Text | English |
| Keyword | Complex; degree of charge transfer; drugs; FT-IR; spectrophotometry; thermodynamics; vertical ionization potential |