Short-term exposure to the peroxisome proliferators, perfluorooctanoic acid and perfluorodecanoic acid, causes significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats
Takagi, A; Sai, K; Umemura, T; Hasegawa, R; Kurokawa, Y
HERO ID
2325496
Reference Type
Journal Article
Year
1991
Language
English
PMID
| HERO ID | 2325496 |
|---|---|
| In Press | No |
| Year | 1991 |
| Title | Short-term exposure to the peroxisome proliferators, perfluorooctanoic acid and perfluorodecanoic acid, causes significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats |
| Authors | Takagi, A; Sai, K; Umemura, T; Hasegawa, R; Kurokawa, Y |
| Journal | Cancer Letters |
| Volume | 57 |
| Issue | 1 |
| Page Numbers | 55-60 |
| Abstract | To elucidate the relationship between peroxisome proliferation by perfluorinated compounds and oxidative DNA damage, perfluorooctanoic acid (PFOA), perfluorodecanoic acid (PFDA), perfluorobutyric acid (PFBA) and perfluorooctane (PFO) were administered to 6-week-old F-344 male rats. After a single intraperitoneal (i.p.) injection of PFOA, PFBA or PFO in corn oil at a dose of 100 mg/kg, significant increases of liver weight and 8-hydroxydeoxyguanosine (8-OH-dG) levels in liver DNA were observed in PFOA-treated rats. Oral administration of powdered diet containing 0.02% PFOA or 0.01% PFDA for 2 weeks resulted in significant increases of liver weight and 8-OH-dG levels in liver DNA in rats given both chemicals. On the other hand, no increase in 8-OH-dG levels in kidney DNA was found in either of the studies. Our results demonstrate that, as with other peroxisome proliferators (phthalic ester plasticizers and hypolipidemic drugs), PFOA and PFDA induced peroxisome proliferation also leads to organ specific oxidative DNA damage. |
| Doi | 10.1016/0304-3835(91)90063-N |
| Pmid | 2025879 |
| Wosid | WOS:A1991FJ28600009 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: CANCER LETT 57 ISSN:Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025802981&doi=10.1016%2f0304-3835%2891%2990063-N&partnerID=40&md5=70ad2a632d5557cd48a6140cd7fc4d80 |
| Is Public | Yes |
| Language Text | English |
| Keyword | peroxisome proliferators; perfluorooctanoic acid; perfluorodecanoic acid; 8-hydroxydeoxyguanosine; oxidative DNA damage |