Ageing and gut microbes: Perspectives for health maintenance and longevity
Biagi, E; Candela, M; Turroni, S; Garagnani, P; Franceschi, C; Brigidi, P
| HERO ID | 2280465 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2013 |
| Title | Ageing and gut microbes: Perspectives for health maintenance and longevity |
| Authors | Biagi, E; Candela, M; Turroni, S; Garagnani, P; Franceschi, C; Brigidi, P |
| Journal | Pharmacological Research |
| Volume | 69 |
| Issue | 1 |
| Page Numbers | 11-20 |
| Abstract | The ageing process affects the human gut microbiota phylogenetic composition and its interaction with the immune system. Age-related gut microbiota modifications are associated with immunosenescence and inflamm-ageing in a sort of self-sustaining loop, which allows the placement of gut microbiota unbalances among both the causes and the effects of the inflamm-ageing process. Even if, up to now, the link between gut microbiota and the ageing process is only partially understood, the gut ecosystem shows the potential to become a promising target for strategies able to contribute to the health status of older people. In this context, the consumption of pro/prebiotics may be useful in both prevention and treatment of age-related pathophysiological conditions, such as recovery and promotion of immune functions, i.e. adjuvant effect for influenza vaccine, and prevention and/or alleviation of common "winter diseases", as well as constipation and Clostridium difficile-associated diarrhoea. Moreover, being involved in different mechanisms which concur in counteracting inflammation, such as down-regulation of inflammation-associated genes and improvement of colonic mucosa conditions, probiotics have the potentiality to be involved in the promotion of longevity. |
| Doi | 10.1016/j.phrs.2012.10.005 |
| Pmid | 23079287 |
| Wosid | WOS:000315831100002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Intestinal microbiota; Ageing; Immunosenescence; Probiotics; Longevity |