Circadian and 30 minutes variations in serum TSH and thyroid hormones in normal subjects
Weeke, J; Gundersen, HJG
HERO ID
2238556
Reference Type
Journal Article
Year
1978
Language
English
PMID
| HERO ID | 2238556 |
|---|---|
| In Press | No |
| Year | 1978 |
| Title | Circadian and 30 minutes variations in serum TSH and thyroid hormones in normal subjects |
| Authors | Weeke, J; Gundersen, HJG |
| Journal | European Journal of Endocrinology |
| Volume | 89 |
| Issue | 3 |
| Page Numbers | 659-672 |
| Abstract | Ten normal young males were investigated in order to examine diurnal and short-term variations in serum TSH and serum thyroid hormones. In five subjects blood samples were obtained every 30 min during a 24 h period of daily life. A synchronous diurnal rhythm was found for free T3 and serum TSH with low levels in the day-time and higher levels at night. The mean increase from day to night was 15 and 140 per cent, respectively. There was a tendency to a similar rhythm in free T4, but the increase of 7 per cent fell short of statistical significance. In the other five men blood samples were obtained every 5 min in a 6 to 7 h period starting within the interval from 19.15 to 22.00 h. A significant regular variation with a cycle-length of half an hour was found in TSH, free T3 and free T4. This rhythm accounted for a significant part of the total variation in the levels of TSH, free T3 and free T4. The mean amplitude of the short-term variation is 13, 15 and 11 per cent of the mean level of the respective hormones. The data suggest a pulsatile release of hormones from the thyroid gland governed by a pulsatile TSH secretion. |
| Doi | 10.1530/acta.0.0890659 |
| Pmid | 716774 |
| Wosid | WOS:A1978FZ65400004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |