The synergetic effect of ambient PM2.5 exposure and rhinovirus infection in airway dysfunction in asthma: A pilot observational study from the central valley of california
Vempilly, J; Abejie, B; Diep, V; Gushiken, M; Rawat, M; Tyner, TR
| HERO ID | 2232574 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | The synergetic effect of ambient PM2.5 exposure and rhinovirus infection in airway dysfunction in asthma: A pilot observational study from the central valley of california |
| Authors | Vempilly, J; Abejie, B; Diep, V; Gushiken, M; Rawat, M; Tyner, TR |
| Journal | Experimental Lung Research |
| Volume | 39 |
| Issue | 10 |
| Page Numbers | 434-440 |
| Abstract | <strong>BACKGROUND: </strong>Elevated levels of particulate matter PM2.5 and rhinovirus infection have been known to exacerbate asthma. However, the combined effect of rhinovirus infection and high PM2.5 has not been investigated.<br /><br /><strong>PURPOSE: </strong>To investigate the effect of PM2.5 and concomitant rhinovirus infection on airway function in asthma in an area with high PM2.5 concentration.<br /><br /><strong>METHODS: </strong>Asthmatics and their matched controls were monitored for lung function, exhaled nitric oxide (eNO) and respiratory symptoms on days with varying levels of PM2.5. As the study was a repeated measure design, repeated clinical findings, and laboratory data were used in the mixed model analysis.<br /><br /><strong>RESULTS: </strong>Wheezing and dyspnea in asthmatics were worsened with increasing ambient PM2.5. Increasing PM2.5 decreased FEV1% predicted (-0.51, -0.79 to -0.23) and FEF25-75% predicted (-0.66, -1.07 to -0.24) in subjects with asthma (all P < .01). Rhino viral infection reduced FEF25-75% predicted in subjects with asthma (-11.7, -20 to -2.9). The reductions in FEV25-75 and FEV1 per 10 μg/m(3) increase in ambient PM2.5 were 6% and 5% respectively. A significant interaction was observed between presence of rhinovirus infection and elevated PM2.5 in asthmatics causing a 4-fold decrease in FEF25-75 (P = .01) and a 2-fold decrease in FEV1% predicted values (P = .01) compared with asthmatics with no rhino viral infection.<br /><br /><strong>CONCLUSIONS: </strong>Increasing ambient PM2.5 and low temperature independently worsened airway function in asthma. The interaction between rhinovirus and PM2.5 significantly impairs airway function in asthma. A larger sample size study is suggested to investigate these observations. |
| Doi | 10.3109/01902148.2013.840693 |
| Pmid | 24245976 |
| Wosid | WOS:000327846400003 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | air pollution; exhaled nitric oxide; FEV1; nonatopic; PM2.5; Rhinovirus |